# life: inside the mysterious (i.e. secret) Yunnan cave, a key to the bizarre jump of the Chinese covid-19 virus

<< In 2004, deep in the wilderness of China’s Yunnan province, a group of scientists from the Wuhan Institute of Virology discovered a cave full of wild bats carrying hundreds of SARS-related viruses. Their work, published in a draft paper in 2005, ( Science. 2005 Oct 28;310(5748):676-9. Epub 2005 Sep 29.  https://www.ncbi.nlm.nih.gov/pubmed/16195424 ) unearthed the link between SARS (severe acute respiratory syndrome) and bats for the first time. >>

<< Now the virologist who led that study, Shi Zhengli, has revealed one of the strains found in that cave - the exact location of which is a closely guarded secret - is almost identical to the 2019-nCoV coronavirus which has so far killed at least 1,115 people and infected more than 45,000 worldwide. >>

<< Professor Shi ran the genome sequence of 2019-nCoV - now officially known as COVID-19 - through the bat-related virus database she built up over ten years and found it was a 96 per cent match to a virus found in the droppings of horseshoe bats. >>

Marnie O’Neill. Mysterious bat cave in Chinese wilderness could hold key to coronavirus. news.com.au Feb 13, 2020.

https://www.news.com.au/lifestyle/health/health-problems/mysterious-bat-cave-in-chinese-wilderness-could-hold-key-to-coronavirus/news-story/530063aeb9de7020e626f1c4839b9777

Also

Zhou, P., Yang, X., Wang, X. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. doi: 10.1038/s41586-020-2012-7. Jan 29, 2020.

https://www.nature.com/articles/s41586-020-2012-7

Human uses of bats (also in chinese traditional medicine). Wikipedia. Last edited 11 days ago by Enwebb.

https://en.m.wikipedia.org/wiki/Human_uses_of_bats

Bat as food. Wikipedia. Last edited 7 days ago by Enwebb.

https://en.m.wikipedia.org/wiki/Bat_as_food

# s-epidem: diurnal mosquitoes with Zika virus inside

<< Experts are concerned that the illness, which is increasingly linked to a disorder that causes paralysis, may become a problem in the U.S. >>

Dina Fine Maron. Zika Disease: Another Reason to Hate Mosquitoes.  October 8, 2015

http://www.scientificamerican.com/article/zika-disease-another-reason-to-hate-mosquitoes/

A new global map highlights places #Zika could spread

https://twitter.com/ScienceNews/status/690677908927598593

Meghan Rosen. Rapid spread of Zika virus in the Americas raises alarm. Mosquito-borne disease linked to birth defect is pushing northward from Brazil. 3:08PM, January 22, 2016

https://www.sciencenews.org/article/rapid-spread-zika-virus-americas-raises-alarm

# evol: viruses as a facilitator / driver of horizontal gene transfer among eukaryotes

<< Gene exchange between viruses and their hosts acts as a key facilitator of horizontal gene transfer and is hypothesized to be a major driver of evolutionary change. Our understanding of this process comes primarily from bacteria and phage co-evolution, but the mode and functional importance of gene transfers between eukaryotes and their viruses remain anecdotal. >>

AA << systematically characterized viral–eukaryotic gene exchange across eukaryotic and viral diversity, identifying thousands of transfers and revealing their frequency, taxonomic distribution and projected functions. Eukaryote-derived viral genes, abundant in the Nucleocytoviricota, highlighted common strategies for viral host-manipulation, including metabolic reprogramming, proteolytic degradation and extracellular modification. Furthermore, viral-derived eukaryotic genes implicate genetic exchange in the early evolution and diversification of eukaryotes, particularly through viral-derived glycosyltransferases, which have impacted structures as diverse as algal cell walls, trypanosome mitochondria and animal tissues. These findings illuminate the nature of viral–eukaryotic gene exchange and its impact on the evolution of viruses and their eukaryotic hosts. >>️

Irwin, N.A.T., Pittis, A.A., Richards, T.A. et al. Systematic evaluation of horizontal gene transfer between eukaryotes and viruses. Nat Microbiol. doi: 10.1038/ s41564-021-01026-3. Dec 31, 2021. 

https://www.nature.com/articles/s41564-021-01026-3

<< We knew from individual examples that viral genes have played a role in the evolution of eukaryotes. Even humans have viral genes, which are important for our development and brain function, (..)  We wanted to understand more broadly how HGT (horizontal gene transfer) has affected viruses and eukaryotes from across the tree of life. >> Nicholas Irwin. ️

<< We were interested to find that certain groups of viruses, especially those that infect single-celled eukaryotes, acquire a lot of genes from their hosts, (..)  By studying the function of these genes we were able to make predictions about how these viruses affect their hosts during infection. >> Patrick Keeling.

<< Many of these viral-derived genes appear to have repeatedly affected the structure and form of different organisms, from the cell walls of algae to the tissues of animals, (..) This suggests that host-virus interactions may have played an important role in driving the diversity of life we see today. >> Nicholas Irwin. ️

<< These transfers not only have evolutionary consequences for both virus and host, but could have important health implications, >> Patrick Keeling.️

<< we think that this work serves as an interesting reminder that viruses have also contributed to the evolution of life on Earth, >>️ Nicholas Irwin. 

️

New research shows gene exchange between viruses and hosts drives evolution. University of British Columbia. Jan 5, 2022.

https://phys.org/news/2022-01-gene-exchange-viruses-hosts-evolution.html

Also

Nonlinear effects in shaping human evolution, the role of viruses. Jan 15, 2019. 

https://flashontrack.blogspot.com/2019/01/evol-nonlinear-effects-in-shaping-human.html

keyword 'evolution'  in FonT

https://flashontrack.blogspot.com/search?q=evolution

keyword 'evolution' | 'evoluzione'  in Notes (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=evolution

https://inkpi.blogspot.com/search?q=evoluzione

Keywords: evolution, virus, gene exchange, horizontal gene transfer, HGT

# gst: NS3, how viruses self-cripple their genome replication machinery

<< An interdisciplinary team of researchers (..) has used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. Based on their research, the team said these viruses appear to cripple their own genome replication machinery.  >>

<< Nonstructural Protein 3 - or NS3 - in flaviviruses, (..) cause a number of diseases in humans. NS3 is a key enzyme that these viruses use to copy their genomes. >>

<< Most vaccines are developed by finding random mutations that slow down virus growth, (..) By understanding how viral enzymes like NS3 work in great detail, we can use that information to rationally design new mutant viruses that replicate less well and act better as a vaccine, without having to rely on chance to make the vaccine. This can help develop vaccines more rapidly and precisely. >> Brian Geiss.

New details on how a viral protein puts the brakes on virus replication. Colorado State University.  Feb 7, 2020.

https://m.phys.org/news/2020-02-viral-protein-virus-replication.html

Kelly E. Du Pont, Russell B. Davidson,  et al. Motif V regulates energy transduction between the flavivirus NS3 ATPase and RNA-binding cleft. The Journal of Biological Chemistry 295, 1551-1564. Feb 7, 2020.

http://m.jbc.org/content/295/6/1551

Also

keyword 'NS3 enzyme' in ncbi

https://www.ncbi.nlm.nih.gov/m/pubmed/?term=NS3+enzyme

# life: Hollywood movies revisited, you'll have to be very careful, a cycle of panic and neglect (e.g. about an 'Entity X') is beginning to repeat.

<< Your Highnesses, Your Excellencies,

Dear colleagues and friends, (..).

I thank Your Highnesses for your hospitality, for your steadfast support for the World Health Organization and global health, and for the opportunity to address you today.  >>️

<< On the 12th of February 2018 – exactly six years ago – I stood on this stage and said the world was not prepared for a pandemic, and expressed my concern at that time that a pandemic could happen anytime. >>️

<< As you remember, less than two years later, in December 2019, the COVID-19 pandemic struck, and indeed, the world was not prepared. >>️

<< Today I stand before you, in the aftermath of COVID-19,

With millions of people dead,

With social, economic and political shocks that reverberate to this day, >>️

<< The cycle of panic and neglect is beginning to repeat. >>️

<< It may be caused by an influenza virus, or a new coronavirus, or it may be caused by a new pathogen we don’t even know about yet – what we call Disease X. >>️

WHO Director-General's speech at the World Governments Summit – 12 Feb 2024.️ WHO. 

https://www.who.int/director-general/speeches/detail/who-director-general-s-speech-at-the-world-governments-summit---12-february-2024   

Also: sars, covid, 1or2achoos, virus, in https://www.inkgmr.net/kwrds.html

Keywords: sars, covid, 1or2achoos, virus, disease X

# ecol: mycological jazz

<< "Mycological" draws conceptually from fungal networks in forests and their interactions. Inspired by the work of ecologist Suzanne Simard, author Michael Pollan, and mycologist Paul Stamets; Krolak saw many parallels between biological networks and the social network known as jazz, as well as, the acoustic networks created when musicians interact through their instruments. Aesthetically, the work is of the free and avant-garde traditions of jazz. Drawing inspiration from John Coltrane to Sonny Sharrock to Makaya McCraven, Krolak seeks to create a space for various elements to play out and find their own connections. >>

Mycological By Nicholas Krolak. All About Jazz. Jan 8, 2022. 

https://www.allaboutjazz.com/media/track-mycological-by-nicholas-krolak

Also

Apropos of 'mycological jazz', a old  perplexity of mine, who knows why substantial funds were no longer allocated to sci research on viruses, bacteria, fungi (..) and their ecological 'jazzy interactions' ... ? 😏

keyword 'virus' | 'bacteria' | 'fungi' in FonT

https://flashontrack.blogspot.com/search?q=virus

https://flashontrack.blogspot.com/search?q=bacteria

https://flashontrack.blogspot.com/search?q=fungi

Also

Much of intelligence (quasi-stochastic poetry). Notes. Dec 16, 2005.

https://inkpi.blogspot.com/2005/12/1929-much-of-intelligence.html

keyword 'jazz' in FonT

https://flashontrack.blogspot.com/search?q=jazz

keyword 'jazz' in Notes (quasi-stochastic poetry):

https://inkpi.blogspot.com/search?q=jazz

Keywords: jazz, viruses, bacteria, fungi, interactions, acad, scires, funds

# life: simnotrelvir, a Chinese pill anti covid-19

<< A drug called simnotrelvir speeds up recovery from mild to moderate COVID-19 by about 1.5 days, relieving symptoms such as fever, cough and runny nose.  >>

<< Whether it can help people who are at high risk of hospitalization and death from COVID-19 is still unclear. >>️️

Saima Sidik. Potent new pill provides COVID relief for the masses. Nature. doi: 10.1038/d41586-024-00117-5. Jan 17,  2024. 

https://www.nature.com/articles/d41586-024-00117-5

Bin Cao, Yeming Wang, et al. Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19. N Engl J Med 2024; 390:230-241. doi: 10.1056/NEJMoa2301425. Jan 18, 2024.

https://www.nejm.org/doi/10.1056/NEJMoa2301425

FonT: if it is (another) 'pastroky', you can redirect yourself towards an alcohol plus peroxide solution... just to put the classic patch on it. 

Also:  a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia. FonT. Oct 4, 2023. 

https://flashontrack.blogspot.com/2023/10/life-proposito-di-1or2achoos-da-wuhan.html

Also: 1or2achoos, sars, covid, virus, pastroky, in:   https://www.inkgmr.net/kwrds.html

Keywords: life, virus, flu, coronavirus,  sarscov2, covid19, 1or2achoos, mask

# life: apropos of 1or2achoos (from Wuhan (?)) ; CD8+ T cell and early mucosal IgA responses seem strongly associated with viral (SARS-CoV-2) control.

<< the earliest stages of SARS-CoV-2 infection remain poorly characterized. Wagstaffe et al. conducted a human SARS-CoV-2 infection challenge study, enabling analysis of the innate and adaptive immune responses during the early postexposure period. (..) Modeling of the immune response identified CD8+ T cell and early mucosal IgA responses as strongly associated with viral control, >> Claire Olingy.  ️

Helen R. Wagstaffe, Ryan S. Thwaites, et al. Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults. Sci Immunol. Vol 9, Issue 92. doi: 10.1126/ sciimmunol.adj9285. Feb 9, 2024. 

https://www.science.org/doi/10.1126/sciimmunol.adj9285   

Also: aproposito di '1or2achoos' (da Wuhan (?)). FonT.  jul 13, 2022. 

https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html 

Also: sars, covid, 1or2achoos, virus, in  https://www.inkgmr.net/kwrds.html

Keywords:  sars, covid, 1or2achoos, virus, mucosa, early viral control 

# life: a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia

a proposito di '1or2achoos' (da Wuhan (?)), qui la cronologia di inizio dei 6 flu|covid che ho contratto dal gen2020 ad oggi con i relativi tempi di 'smorzamento' dell'infezione, trattati nebulizzando una miscela di alcool e H2O2 ( https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html )

(1) 2020.04.11-16:04 ~12h (non vaccinato)

(2) 2021.09.01-07:40 ~12h (non vaccinato)

(3) 2022.06.11-08:26 18-36h (+1mese post vaccino, 3dosi)

(4) 2022.12.24-07:52 ~24h 

(5) 2023.02.28-12:09 ~24h 

(6) 2023.04.08-09:32 24-36h 

I tempi necessari per 'spegnere' questi  flu|covid sono tutti notevolmente inferiori (~80%) rispetto alle pregresse forme di flu che ho contratto delle quali ho memoria.

Invece non ho altre parole da aggiungere per commentare i diversi argomenti associabili a '1or2achoos' dal febbraio 2020 ad oggi.

Potrei (e.g. expectedepidemic, lockdown, greenpass, indicatori, statistiche, accademieacucciabili, sadichepredazioni, bucodibilancio, pastroky, ...) nelle bizzarre forme della poetica quasistocastica ( https://inkpi.blogspot.com/ ), ma mi astengo.

Anche: "Ricordo che quando si era ragazzi". in: "il pino di takata matsubara". Notes. Apr 1, 2011. https://inkpi.blogspot.com/2011/04/2157-il-pino-di-takata-matsubara.html

Anche: "e Da-Li' si sparse pell'aere". in: "cracker tendenziali". Notes. Apr 4, 2008. https://inkpi.blogspot.com/2008/04/cracker-tendenziali-around-matter.html

Anche: "in attesa del beffardo tsunami". in: "onda di carambola". Notes. Nov 29, 2004. 

https://inkpi.blogspot.com/2004/11/1619-onda-di-carambola.html

Anche: "aproposito di '1or2achoos' (da Wuhan (?)) ...". FonT. Jul 13, 2022. https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html

Anche: 1or2achoos, sars, covid, virus, pastroky, in: 

https://www.inkgmr.net/kwrds.html

Keywords: life, virus, flu, coronavirus,  sarscov2, covid19, 1or2achoos, mask

# life: apropos of 'dancing at a fixed point'

the last interview to Dr Albert Bourla (Pfizer) about the annual (or maybe semi-annual (?)) shot reiteration of the vaccine against #sars-cov-2   remember to me the 'homoclinic dynamics' that I cited at the 13th Meeting of the Internat Epidemiol Associat - IEA (Sydney, 1993) ... after a large trajectories started at zero point (i.e.  the fixed point), the final point of the dynamic returns at the same zero point ...

<< People will be likely to need to have annual Covid vaccinations for many years to come, the head of Pfizer [Dr Albert Bourla ] has told the BBC >>️

Fergus Walsh. Pfizer boss: Annual Covid jabs for years to come. Dec 2, 2021. 

https://www.bbc.com/news/health-59488848

Who knows if there is a convincing reason that explains why to treat a virus with a high frequency of mutations one should prefer a vaccine approach instead of an antiviral drug ...

to find: 'antiviral drugs covid-19'  

https://pubmed.ncbi.nlm.nih.gov/?term=antiviral+drugs+covid-19&filter=datesearch.y_1

Apropos of 'homoclinic orbits' ...

<< the reinjection of the departing trajectories in the vicinity of an unstable fixed point of the saddle-focus type [..] is frequently associated with the emergence of orbits of a rather exceptional type known as 'homoclinic orbits'. These are trajectories that leave the fixed point but come back to it; in other words, they tend to the same limit when time t goes to +∞ as well as to -∞ . [..]. Homoclinic orbits are very sensitive to variation of parameter [parms] values and are generally destroyed if the [parms] do not satisfy a strict equality (in the terminology of [..] they are structurally unstable). However, for nearby values of the [parms] their disappearance leaves a very rich structure of orbit in phase space, some of which behave chaotically. >>️

Nicolis G., Prigogine I. Exploring complexity. Freeman, NY (1989): 130-131.

https://www.amazon.com/Exploring-Complexity-Introduction-Gregoire-Nicolis/dp/0716718596

Apropos of: [+∞ , -∞] plus infinity, minus infinity; 

<< In modern mysticism, the infinity symbol has become identified with a variation of the ouroboros, an ancient image of a snake eating its own tail that has also come to symbolize the infinite, [..] >> 

https://en.m.wikipedia.org/wiki/Infinity_symbol

Also 

Onda omoclina. Notes. Tuesday, Jan  11, 2005 (quasi-stochastic poetry)

<< ed assistere al mutar dell' onda omoclina / (..) >>

️

https://inkpi.blogspot.com/2005/01/1639b-onda-omoclina.html

Also

Inchingolo GM.  Cultural transitions and epidemiology.  Proceedings of the 13th Scientific Meeting of the International Epidemiological Association - IEA, Sydney, Australia, Sept 26-29, 1993: 129.   Med Hypotheses 1994; 43(4): 201-206.

https://pubmed.ncbi.nlm.nih.gov/7838001/

Also

Onda di carambola. Notes. Nov  29, 2004. (quasi-stochastic poetry)

https://inkpi.blogspot.com/2004/11/1619-onda-di-carambola.html

keywords: life, dance, fixed point, homoclinic orbits, instability, chaos,  virus, coronavirus, sars-cov-2,  covid19, 2019ncov, drugs, antiviral drug, vaccine, jabs, Covid jabs.

# life; the hypothesis of early treatment (at home) of the virus sars-cov-2

Figure 1 - Proposed maladaptive hyperinflammatory response to SARS-CoV-2 infection (Perico N, Cortinovis M, Suter F, Remuzzi G. (2022))

<< A few observational studies have tested NSAIDs [non-steroidal anti-inflammatory drugs] (especially  relatively selective COX-2 inhibitors), often as part of multipharmacological protocols, for early outpatient treatment of COVID-19. The findings from these studies are promising and point to a crucial role of NSAIDs for the at-home management of people with initial COVID-19 symptoms. >>

<< Celecoxib, ibuprofen, and nimesulide should be avoided in children younger than 12 years, whereas aspirin should be taken only under prescription and at the dose recommended by the family doctor. >>️

️

Norberto Perico, Monica Cortinovis, Fredy Suter, Giuseppe Remuzzi. Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents. The Lancet Infectious Diseases. doi: 10.1016/ S1473-3099(22)00433-9. Aug 25, 2022. 

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00433-9/fulltext

FonT

therefore the deadly infection by sars-cov-2 that has generated so much suffering,  pain, and dead everywhere it is recently hypothesized that it could easily be treated at home (an early treatment) with some success.

Also

keywords 'covid-19' and 'NSAIDs' in PubMed

https://pubmed.ncbi.nlm.nih.gov/?term=covid-19+NSAIDs&filter=datesearch.y_1

Also

aproposito di '1or2achoos' (da Wuhan (?)) ... FonT. Jul 13  2022.

https://flashontrack.blogspot.com/2022/07/life-aproposito-di-1or2achoos-da-wuhan.html

Keywords: virus, coronavirus,  sarscov2, 2019ncov, covid19, 1or2achoos

# life: 27 proteins to confine a world to a (complex 3D) virus dance

<< The novel coronavirus sweeping the globe packs 27 proteins, each adopting a unique, often incredibly complex 3D structure. 

Each protein is part of the molecular toolkit that the virus uses to infect, replicate, and spread. >>

Tom Rickey. Scientists Take Aim at the Coronavirus Toolkit. PNNL. Mar 31, 2020.

https://www.pnnl.gov/news-media/scientists-take-aim-coronavirus-toolkit

https://phys.org/news/2020-04-scientists-aim-coronavirus-toolkit.html

Also 

keyword 'dance' in FonT 

https://flashontrack.blogspot.com/search?q=dance

Also (quasi-stochastic poetry)

Catalisi d'astrattivo Tao. FonT.  Jan 22, 2005.

https://inkpi.blogspot.com/2005/01/1808-catalisi-dastrattivo-tao.html

# behav: how a microbiota (Curvibacter sp.) could modulate eating behavior in Hydra.

(AA) << studied the eating behavior of Hydra, a host that has a simple nervous system and a low-complexity microbiota. >>

(They) << demonstrate that different neuronal subpopulations are functioning together to control the eating behavior. The microbiota participates in control of the eating behavior since germ-free or mono-colonized animals have drastic difficulties in mouth opening. This was restored by adding a full complement of the microbiota. >>️

The << findings confirm and expand on the idea that in animals without a central nervous system, a complex behavior is controlled by multiple subpopulations of neurons, forming circuits and modules. (Their)  observations presented here show that this not only requires the coordination of multiple neuronal circuits, but also that signals from the microbial environment play an important role. >>

Christoph Giez, Denis Pinkle, et al.  Microbes as part of ancestral neuronal circuits: Bacterial produced signals affect neurons controlling eating behavior in Hydra. BioRxiv. doi: 10.1101/ 2023.04.28.538719. Apr 29, 2023. 

https://www.biorxiv.org/content/10.1101/2023.04.28.538719v1

Also: How a virus could cause context-dependent manipulation in host social behavior.  Apr 28, 2020.  https://flashontrack.blogspot.com/2020/04/gst-how-virus-could-cause-context.html

Keywords: behav, eating behavior, food, Hydra, microbiota 

# pnei: brain motor and fear circuits regulate leukocytes during acute stress

<< The nervous and immune systems are intricately linked. Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remain poorly understood. Here, (AA) show that distinct brain regions shape leukocyte distribution and function throughout the body during acute stress in mice. >>️

Poller, W.C., Downey, J., et al. Brain motor and fear circuits regulate leukocytes during acute stress. Nature. doi: 10.1038/ s41586-022-04890-z. May 30, 2022. 

https://www.nature.com/articles/s41586-022-04890-z

PNEI: Psycho-Neuro-Endocrine-Immunology  

https://pubmed.ncbi.nlm.nih.gov/?term=pnei

Also

Inchingolo G. Percezione dello stato di salute e leucociti in anziani ultraottantenni.   Atti 36 Congresso Nazionale Società Italiana di Gerontologia e Geriatria, Palermo, 7-10 Novembre 1991.   Giornale di Gerontologia 1991; XXXIX(11): 753.

https://sites.google.com/site/inkgmr2/papers

keyword 'pnei' | in FonT

https://flashontrack.blogspot.com/search?q=pnei

keyword 'pnei' | in Notes 

 (quasi-stochastic poetry)

https://inkpi.blogspot.com/search?q=pnei

Keywords: pnei, neuroimmunology, leukocytes, fear, stress, virus, viral infection, adaptation, adaptive immunity 

# gst: observing the crystallization process in a droplet

<< Crystallization is the assembly of atoms or molecules into highly ordered solid crystals, which occurs in natural, biological, and artificial systems. However, crystallization in confined spaces, such as the formation of the protein shell of a virus, is poorly understood. Researchers are trying to control the structure of the final crystal formed in a confined space to obtain crystals with desired properties, which requires thorough knowledge of the crystallization process. >>

AA << used a droplet of a colloid—a dispersion of liquid particles in another liquid, like milk—as a model for single atoms or molecules in a sphere. Unlike single atoms or molecules, which are too small to easily observe, the colloid particles were large enough to visualize using a microscope. This allowed the researchers to track the ordering of single particles in real time during crystallization. >>

<< We visualized the organization process of colloid particles in numerous droplets under different conditions to provide a picture of the crystallization process in a sphere, >> Peng Tan

<< Based on their observations, the team proposed that the crystallization process involved three stages: initial ordering on the surface "skin" of the droplet, nucleation and growth in the core of the droplet, and then slow ripening of the whole structure. First, a skin consisting of a single layer of ordered colloid particles rapidly formed on the droplet surface. Next, crystallization occurred in the core of the droplet, far from the crystallized skin. The competition between crystallization in these two regions controlled the structure of the final crystal. The researchers found that the "soft" (long-range) interactions between the negatively charged colloid particles affected their organization and the resulting crystal structure. These soft interactions are dominated by kinetics, that is, the interactions that form the fastest, rather than those that use the least energy to give the thermodynamically stable structure, illustrating that kinetics plays an important role in crystallization in a confined space. It was already known that thermodynamics contributes strongly to the final structure of crystals. >>

Having a ball: Crystallization in a sphere. University of Tokyo. Sep 21, 2020.

https://phys.org/news/2020-09-ball-crystallization-sphere.html

Chen Y., Yao Z., et al. Morphology selection kinetics of crystallization in a sphere. Nat. Phys. doi: 10.1038/ s41567-020-0991-9. Sep 21, 2020.

https://www.nature.com/articles/s41567-020-0991-9

Also

Control of material crystallization by agitation. Osaka University. Jun 08, 2017.

https://phys.org/news/2017-06-material-crystallization-agitation.html

keyword 'drop' or 'droplet' in FonT

https://flashontrack.blogspot.com/search?q=drop

https://flashontrack.blogspot.com/search?q=droplet

# rmx-trade: il grande disastro del carrello del the' per Egon

<< $1.5 Quadrillion Derivatives Bomb And The Great Financial Disaster >>

http://kingworldnews.com/1-5-quadrillion-derivatives-bomb-and-the-great-financial-disaster/

Egon von Greyerz, fondatore e managing partner della società svizzera Matterhorn Asset Managment, riferendosi alla bomba di derivati mondiale, che avrebbe un valore di ben $1,5 quadrilioni di dollari, parla del Grande Disastro Finanziario che si abbatterà sul pianeta ...

http://www.wallstreetitalia.com/article/1830890/finanza/un-grande-disastro-finanziario-si-abbattera-sul-pianeta.aspx

also: "the Great Tea Trolley Disaster", Bristow

http://www.frankdickens.com/

also: a rhyming, quasistochastics, "Future movers"

<< N. sull'esplorazione del fruticoso di verdure di mutico col neuroSurfer dal curvimetro ceduo, occamista, in traccia di mude nel cesto dalle ferule nervature interferenti a refuso di turme sdrucciolevoli, superconduttive - come trattate da un virus dalle femto cesure crude, giammai dome - nel pervasivo furore di merci ch'autoescludevano ... // >>

Inchingolo GM, Sunday, April 23, 2006

http://inkpi.blogspot.it/2006/04/1995-future-movers.html

# s-brain: imprinting and recalling inside a single network of brain cells with thin beam of light (as if switching on a TV ) ...

<< a set of neurons trained to fire in unison could be reactivated as much as a day later if just one neuron in the network was stimulated. >>

AA <<  injected the mouse with a virus containing light-sensitive proteins engineered to reach specific brain cells. Once inside a cell, the proteins allowed researchers to remotely activate the neuron with light, as if switching on a TV >>

<< But then I saw the results and said "Holy moly, this whole thing is plastic". We're dealing with a plastic computer that's constantly learning and changing >>  Rafael Yuste.

Researchers Reprogram Network of Brain Cells in Mice With Thin Beam of Light. Neuroscience News. August 11, 2016

http://neurosciencenews.com/optogenetics-brain-plasticity-4832/

Luis Carrillo-Reid, Weijian Yang, et al. Imprinting and recalling cortical ensembles. Science.12 Aug 2016: Vol. 353,  Issue  6300,  pp.  691-694 DOI:  10.1126/science.aaf7560.

http://science.sciencemag.org/content/353/6300/691

# epidem: silent invasions, the case of Candida auris.

<< Bacteria are rebelling  >>

<< The germ, a fungus called Candida auris, preys on people with weakened immune systems, and it is quietly spreading across the globe. >>

Matt Richtel,  Andrew Jacobs. DEADLY GERMS, LOST CURES. A Mysterious Infection, Spanning the Globe in a Climate of Secrecy. The rise of Candida auris embodies a serious and growing public health threat: drug-resistant germs. NYT. April 6, 2019.

https://www.nytimes.com/2019/04/06/health/drug-resistant-candida-auris.html

<< The recent rate of emergence of pathogenic fungi that are resistant to the limited number of commonly used antifungal agents is unprecedented. The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals. >>

Matthew C. Fisher, Nichola J. Hawkins, et al.  Worldwide emergence of resistance to antifungal drugs challenges human health and food security. Science  May 18, 2018
Vol. 360, Issue 6390, pp. 739-742  doi: 10.1126/science.aap7999

http://science.sciencemag.org/content/360/6390/739

FonT

Per nostra - di noi umani - fortuna oggi si puo' analizzare, studiare ed eventualmente manipolare in modo fine il codice genetico di virus, batteri, etc. grazie alla tecnica CRISPR, tecnica a suo tempo (e per molto tempo) considerata di nessuna importanza da entita' di alta- altissima luminescenza ...

Eric S. Lander. The Heroes of CRISPR.
Cell. 14 January 2016, Vol.164(1): 18–28, doi:10.1016/j.cell.2015.12.041

http://www.sciencedirect.com/science/article/pii/S0092867415017055

Also: "CRISPR"

https://flashontrack.blogspot.com/search?q=crispr

https://www.ncbi.nlm.nih.gov/m/pubmed/?term=crispr

# evol: nonlinear effects in shaping human evolution, the role of viruses

<< Human evolution used to be depicted as a straight line, gradually progressing from an ape-like ancestor to modern Homo sapiens. But thanks to next-generation sequencing, findings in recent years have shown that it wasn’t quite so orderly. Now, a new study is reporting new details about the role of viruses in shaping evolution, in particular, viral interactions between modern humans and Neanderthals. >>

<< Many Neanderthal sequences have been lost in modern humans, but some stayed and appear to have quickly increased to high frequencies at the time of contact, suggestive of their selective benefits at that time, >> Dmitri Petrov

New study reports the role of viruses in shaping evolution. Oct 5, 2018.

https://thesurg.com/virus-shaping-evolution

AA << hypothesized that interbreeding between Neanderthals and modern humans led to (1) the exposure of each species to novel viruses and (2) the exchange of adaptive alleles that provided resistance against these viruses. >>

David Enard, Dmitri A. Petrov. Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans. Cell. 175 (2) P360-371.E13 Oct 4, 2018.

https://www.cell.com/cell/fulltext/S0092-8674(18)31095-X 

# life: a normal (fuzzy, bizarre) Nature jumping, the little carrier snake that can bite a world ...

<<  Reports indicate that snakes were sold in the local seafood market in Wuhan, raising the possibility that the 2019-nCoV might have jumped from the host species - bats - to snakes and then to humans at the beginning of this coronavirus outbreak. However, how the virus could adapt to both the cold-blooded and warm-blooded hosts remains a mystery. >>

Haitao Guo, Guangxiang “George” Luo, Shou-Jiang Gao. Snakes could be the original source of the new coronavirus outbreak in China. Jan 22, 2020.

https://theconversation.com/snakes-could-be-the-original-source-of-the-new-coronavirus-outbreak-in-china-130364

Wei Ji, Wei Wang, et al. Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross‐species transmission from snake to human. Journal of Medical Virology. doi: 10.1002/jmv.25682. Jan 22, 2020.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25682

Also

here a Brazilian 'relative' of the Chinese snake ...

# life: squeezing jaraca' (Bothrops jararaca). FonT. Dec 24, 2019. 

https://twitter.com/flashontrack/status/1209527656091402243

https://flashontrack.blogspot.com/2019/12/life-squeezing-jaraca-bothrops-jararaca.html